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Langerhans cell histiocytosis lch can affect children and adults with a wide variety of clinical manifestations, including unifocal, singlesystem multifocal, singlesystem pulmonary smokingassociated, or multisystem disease. Objective to analyze associations between sociodemographic characteristics, health conditions, leisuretime physical activity ltpa, pa counseling and perceived barriers to ltpa among. The subject was equipped with 18 markers fig. 1 over the last decade, our understanding of lch has been revolutionized by the discovery of the clonal mapk–extracellular signalregulated kinase erk pathway rasraf.
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